Summary

Name NSFL1C
Full Name NSFL1 cofactor p47
Synonyms UBX domain-containing protein 2C, p97 cofactor p47 | UBXN2C
Primary ID Q9UNZ2
Links - -
Type protein
Relations 2
Function Reduces the ATPase activity of VCP (By similarity). Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro) (PubMed:15498563). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation NSFL1C 0.33
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding CTSL 0.2
Publications: 1 Organism: In Vitro