4.0
Summary
| Name |  TRPC6View Modifications |
| Full Name | Short transient receptor potential channel 6 |
| Synonyms | TrpC6, Transient receptor protein 6, TRP-6 | TRP6 |
| Primary ID | Q9Y210 |
| Links |  -  -  |
| Type | protein |
| Relations | 7 |
| Pathways | Focal segmental glomerulosclerosis |
| Function | Thought to form a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346). Seems not to be activated by intracellular calcium store depletion. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKG1 | down-regulates activity 
phosphorylation
|
TRPC6 | 0.494 |
| Publications: | 2 | Organism: | In Vitro | |
| + | SRC | up-regulates activity 
phosphorylation
|
TRPC6 | 0.434 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TRPC6 | up-regulates activity 
|
PPP3CA | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TRPC6 | up-regulates quantity
relocalization
|
calcium(2+) | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Focal segmental glomerulosclerosis | |||
| + | FYN | up-regulates activity
phosphorylation
|
TRPC6 | 0.504 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | AGT | up-regulates activity
|
TRPC6 | 0.306 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Focal segmental glomerulosclerosis | |||