4.0
Summary
| Name |  COQ6
|
| Full Name | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial |
| Synonyms | Coenzyme Q10 monooxygenase 6 | |
| Primary ID | Q9Y2Z9 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-hexaprenyl-4-hydroxybenzoic acid (HHB) to 3-hexaprenyl-4,5-dihydroxybenzoic acid (DHHB). The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6 (By similarity). Is able to perform the deamination reaction at C4 of 3-hexaprenyl-4-amino-5-hydroxybenzoic acid (HHAB) to produce DHHB when expressed in yeast cells lacking COQ9, even if utilization of para-aminobenzoic acid (pABA) involving C4-deamination seems not to occur in bacteria, plants and mammals, where only C5 hydroxylation of HHB has been shown (PubMed:26260787). |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | COQ6 | form complex 
binding
|
CoQ biosynthetic complex | 0.636 |
| Publications: | 1 | Organism: | Homo Sapiens | |