Summary

Name CTDP1
Full Name RNA polymerase II subunit A C-terminal domain phosphatase
Synonyms TFIIF-associating CTD phosphatase | FCP1
Primary ID Q9Y5B0
Links - -
Type protein
Relations 6
Function Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation CTDP1 0.382
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CTDP1 0.382
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CTDP1 0.332
Publications: 2 Organism: Homo Sapiens