Summary

Name SNX9
Full Name Sorting nexin-9
Synonyms SH3 and PX domain-containing protein 1, Protein SDP1, SH3 and PX domain-containing protein 3A | SH3PX1, SH3PXD3A
Primary ID Q9Y5X1
Links - -
Type protein
Relations 5
Pathways Neurotransmitters release
Function Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate.

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Relations

Regulator Mechanism target score ℹ
+ TNK2up-regulates img/direct-activation.png phosphorylation SNX9 0.521
Publications: 1 Organism: Homo Sapiens
+ SNX9down-regulates img/indirect_inhibition.png EGFR 0.55
Publications: 2 Organism: Homo Sapiens
+ SNX9up-regulates img/direct-activation.png binding DNM2 0.802
Publications: 1 Organism: Homo Sapiens
+ SNX9up-regulates img/direct-activation.png binding DNM1 0.78
Publications: 1 Organism: Homo Sapiens
Pathways:Neurotransmitters release