3.0
Summary
| Name |  ICOS
|
| Full Name | Inducible T-cell costimulator |
| Synonyms | Activation-inducible lymphocyte immunomediatory molecule | AILIM |
| Primary ID | Q9Y6W8 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity). |
Viewer
Search Tools
Refine search:
- by mechanism
- by effect
- by organism:
- by tissue:
- by cell-line
binding