| + |
IL17A | up-regulates activity 
binding
|
IL17R complex |
0.799 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261337 |
|
|
Homo sapiens |
Myofibroblast |
| pmid |
sentence |
| 32024054 |
Importantly, IL-17 was involved in increased collagen production in cardiac fibroblasts in response to HG, with both subunits of the IL-17RA and IL-17RC heterodimer complex being important to mediating this response. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Multiple sclerosis |
| + |
IL17RA | form complex 
binding
|
IL17R complex |
0.531 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261335 |
|
|
Homo sapiens |
Myofibroblast |
| pmid |
sentence |
| 32024054 |
Importantly, IL-17 was involved in increased collagen production in cardiac fibroblasts in response to HG, with both subunits of the IL-17RA and IL-17RC heterodimer complex being important to mediating this response. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL17RC | form complex
binding
|
IL17R complex |
0.531 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261336 |
|
|
Homo sapiens |
Myofibroblast |
| pmid |
sentence |
| 32024054 |
Importantly, IL-17 was involved in increased collagen production in cardiac fibroblasts in response to HG, with both subunits of the IL-17RA and IL-17RC heterodimer complex being important to mediating this response. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL17R complex | up-regulates activity 
|
NfKb-p65/p50 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261338 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 8777726 |
3T3 cells were preincubated with an IL-17Rspecific antiserum and then assayed for NF-KB activation by HVS13. Preincubation with the IL-1 7R antiserum dramatically decreased the NF-KB activity induced by HVSl3 as compared with cells preincubated with an irrelevant rat antiserum (Figure 5C). This result indicated that the engagement of the IL-17R by its ligands induced NF-KB activity. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Multiple sclerosis |
3.0
IL17R complex