| + |
LINC complex | up-regulates activity 
relocalization
|
TTM complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263305 |
|
|
|
|
| pmid |
sentence |
| 30718482 |
Together, we conclude that both the TTM complex and SUN1 (the LINC complex) contribute to the stable telomere–NE association. |
|
| Publications: |
1 |
| + |
TERB2 | form complex 
binding
|
TTM complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263304 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 30718482 |
Meiotic specific proteins TERB1, TERB2, and MAJIN form a stable complex that plays a critical role in regulating the recruitment of telomeres to the NE |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAJIN | form complex
binding
|
TTM complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263303 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 30718482 |
Meiotic specific proteins TERB1, TERB2, and MAJIN form a stable complex that plays a critical role in regulating the recruitment of telomeres to the NE |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TTM complex | up-regulates activity
relocalization
|
Shelterin complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263308 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 33015044 |
The shelterin complex has six proteins, containing TRF1, TRF2, POT1, RAP1, TIN2, and TPP1. The shelterin complex is localized to the chromosome end and protects telomeric DNA (Palm and de Lange, 2008). The TTM complex acts as a “linker” and bridges the LINC and shelterin complexes together. The connection between TTM and shelterin complexes is well-known, which is mediated by TERB1 and TRF1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TTM complex | up-regulates activity
relocalization
|
Cohesin complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263307 |
|
|
|
|
| pmid |
sentence |
| 27025256 |
Terb1 and Sun1 are two key proteins linking the meiotic telomeres to the NE. Terb1 participates in telomere fortification by recruiting cohesins to the site |
|
| Publications: |
1 |
| + |
TERB1 | form complex
binding
|
TTM complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263302 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 30718482 |
Meiotic specific proteins TERB1, TERB2, and MAJIN form a stable complex that plays a critical role in regulating the recruitment of telomeres to the NE |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
TTM complex