| + |
Nucleosome_H3.1t variant | up-regulates 
|
Chromatine_condensation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263728 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20498094 |
A histone H3 variant, H3T, is highly expressed in the testis, suggesting that it may play an important role in the chromatin reorganization required for meiosis and/or spermatogenesis. In the present study, we found that the nucleosome containing human H3T is significantly unstable both in vitro and in vivo, as compared to the conventional nucleosome containing H3.1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Nucleosome_H3.1t variant | down-regulates 
|
Transcritpional_activation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273454 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15623580 |
All these studies indicate the possibility that disruption of nucleosomes can take place independently of replication and can be coupled with transcription.The exchange of core histones on mitotic chromatin at anaphase and telophase observed by FRAP may reflect the replacement of a subset of nucleosomes in genome regions that are transcriptionally reactivated in the earliest parts of the new cell cycle. This interpretation is consistent with evidence of chromatin remodeling and chromatin association with RNA pol II at the anaphase–telophase transition (Fig. 9; Prasanth et al., 2003). In situ incorporation of Br-U for 5 min at the same stage showed little labeling outside of NORs (Fig. 9), suggesting that the majority of transcription is yet to commence at this point. The replacement of core histones conceivably precedes transcription to allow the clearance of promoter regions for factors to engage. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
H2BC11 | form complex 
binding
|
Nucleosome_H3.1t variant |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263727 |
|
|
in vitro |
|
| pmid |
sentence |
| 20498094 |
A histone H3 variant, H3T, is highly expressed in the testis, suggesting that it may play an important role in the chromatin reorganization required for meiosis and/or spermatogenesis. In the present study, we found that the nucleosome containing human H3T is significantly unstable both in vitro and in vivo, as compared to the conventional nucleosome containing H3.1. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
H4C1 | form complex
binding
|
Nucleosome_H3.1t variant |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263726 |
|
|
in vitro |
|
| pmid |
sentence |
| 20498094 |
A histone H3 variant, H3T, is highly expressed in the testis, suggesting that it may play an important role in the chromatin reorganization required for meiosis and/or spermatogenesis. In the present study, we found that the nucleosome containing human H3T is significantly unstable both in vitro and in vivo, as compared to the conventional nucleosome containing H3.1. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
H3-4 | form complex
binding
|
Nucleosome_H3.1t variant |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263725 |
|
|
in vitro |
|
| pmid |
sentence |
| 20498094 |
A histone H3 variant, H3T, is highly expressed in the testis, suggesting that it may play an important role in the chromatin reorganization required for meiosis and/or spermatogenesis. In the present study, we found that the nucleosome containing human H3T is significantly unstable both in vitro and in vivo, as compared to the conventional nucleosome containing H3.1. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
H2AC4 | form complex
binding
|
Nucleosome_H3.1t variant |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263724 |
|
|
in vitro |
|
| pmid |
sentence |
| 20498094 |
A histone H3 variant, H3T, is highly expressed in the testis, suggesting that it may play an important role in the chromatin reorganization required for meiosis and/or spermatogenesis. In the present study, we found that the nucleosome containing human H3T is significantly unstable both in vitro and in vivo, as compared to the conventional nucleosome containing H3.1. |
|
| Publications: |
1 |
Organism: |
In Vitro |
3.0
Nucleosome_H3.1t variant
CPX-2564