| + |
Microprocessor complex | up-regulates 
|
NcRNA_processing |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264850 |
|
|
|
|
| pmid |
sentence |
| 24581491 |
Microprocessor minimally comprises the ribonuclease DROSHA and its double-stranded RNA-binding partner DGCR8 (Denli et al., 2004; Gregory et al., 2004). Microprocessor recognizes pri-miRNA through the stem-loop (Zeng et al., 2005) and the stem-loop-ssRNA junction (Han et al., 2006), and cleaves both the 5′ and 3′ flanking segments to generate pre-miRNA. |
|
| Publications: |
1 |
| + |
DDX5 | up-regulates activity 
binding
|
Microprocessor complex |
0.712 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275659 |
|
|
|
|
| pmid |
sentence |
| 34936874 |
Both the phosphorylation and sumoylation of DDX5 enhance the formation of a DDX5/Drosha/DGCR8 complex, thus promoting microRNA-10b processing. |
|
| Publications: |
1 |
| + |
Microprocessor complex | up-regulates quantity
post transcriptional regulation
|
mir-10b |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275661 |
|
|
|
|
| pmid |
sentence |
| 34936874 |
Both the phosphorylation and sumoylation of DDX5 enhance the formation of a DDX5/Drosha/DGCR8 complex, thus promoting microRNA-10b processing. |
|
| Publications: |
1 |
| + |
DROSHA | form complex 
binding
|
Microprocessor complex |
0.923 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264848 |
|
|
Homo sapiens |
HaCaT Cell |
| pmid |
sentence |
| 24581491 |
Microprocessor minimally comprises the ribonuclease DROSHA and its double-stranded RNA-binding partner DGCR8 (Denli et al., 2004; Gregory et al., 2004). Microprocessor recognizes pri-miRNA through the stem-loop (Zeng et al., 2005) and the stem-loop-ssRNA junction (Han et al., 2006), and cleaves both the 5′ and 3′ flanking segments to generate pre-miRNA. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DGCR8 | form complex
binding
|
Microprocessor complex |
0.923 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264849 |
|
|
Homo sapiens |
HaCaT Cell |
| pmid |
sentence |
| 24581491 |
Microprocessor minimally comprises the ribonuclease DROSHA and its double-stranded RNA-binding partner DGCR8 (Denli et al., 2004; Gregory et al., 2004). Microprocessor recognizes pri-miRNA through the stem-loop (Zeng et al., 2005) and the stem-loop-ssRNA junction (Han et al., 2006), and cleaves both the 5′ and 3′ flanking segments to generate pre-miRNA. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
Microprocessor complex
CPX-3080