| + |
GTF2B | up-regulates activity 
relocalization
|
TFIIF |
0.928 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266193 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27096372 |
Our structures suggest that a primary function of TFIID during PIC assembly is the proper positioning of TBP on the upstream promoter, which ultimately determines the placement of Pol II relative to the TSS. The structures presented here offer a structural framework for understanding the complex mechanism underlying TFIID function, shedding new light into the overlapping roles of TFIID as both a coactivator and a general platform for PIC assembly in the coordination of transcription initiation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GTF2F1 | form complex 
binding
|
TFIIF |
0.962 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266194 |
|
|
in vitro |
|
| pmid |
sentence |
| 18218714 |
Human general transcription factor IIF (TFIIF), a component of the transcription pre-initiation complex (PIC) associated with RNA polymerase II (Pol II), was characterized by size-exclusion chromatography (SEC), electrospray ionization mass spectrometry (ESI-MS), and chemical cross-linking. Recombinant TFIIF, composed of an equimolar ratio of alpha and beta subunits, was bacterially expressed, purified to homogeneity, and found to have a transcription activity similar to a natural one in the human in vitro transcription system. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
GTF2F2 | form complex
binding
|
TFIIF |
0.962 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266195 |
|
|
in vitro |
|
| pmid |
sentence |
| 18218714 |
Human general transcription factor IIF (TFIIF), a component of the transcription pre-initiation complex (PIC) associated with RNA polymerase II (Pol II), was characterized by size-exclusion chromatography (SEC), electrospray ionization mass spectrometry (ESI-MS), and chemical cross-linking. Recombinant TFIIF, composed of an equimolar ratio of alpha and beta subunits, was bacterially expressed, purified to homogeneity, and found to have a transcription activity similar to a natural one in the human in vitro transcription system. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
TFIIF | up-regulates activity
relocalization
|
RNA Polymerase II |
0.724 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266199 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18218714 |
Transcription processes in eukaryotes begin with the formation of a pre-initiation complex (PIC), composed of RNA polymerase II (Pol II) associated with five general transcription factors: TFIIB, TFIID, TFIIE, TFIIF, and TFIIH |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Transcription initiation |
3.0
TFIIF
CPX-79