| + |
Class II MHC:Antigen | up-regulates activity 
binding
|
TCR |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267992 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31001252 |
The interaction of T-cell receptors (TCRs) with self- and non-self-peptides in the major histocompatibility complex (MHC) stimulates crucial signaling events, which in turn can activate T lymphocytes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | T cell activation |
| + |
epitope | form complex 
binding
|
Class II MHC:Antigen |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269479 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33374673 |
The major histocompatibility complex (MHC) molecules, or human leukocyte antigens (HLA) in humans, bind these peptides to present them to T cells that recognise them with their surface T cell receptors (TCR). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LAG3 | down-regulates activity 
binding
|
Class II MHC:Antigen |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275412 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 35413245 |
Binding of LAG-3 to stable peptide-MHC class II limits T cell function and suppresses autoimmunity and anti-cancer immunity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Class II MHC | form complex
binding
|
Class II MHC:Antigen |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267872 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33374673 |
The major histocompatibility complex (MHC) molecules, or human leukocyte antigens (HLA) in humans, bind these peptides to present them to T cells that recognise them with their surface T cell receptors (TCR). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Class II MHC:Antigen | up-regulates 
|
Helper_T-lymphocyte_activation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267874 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31810556 |
Once they are formed, peptide/MHC class II molecules complexes are very stable and allow for sustained antigen presentation increasing the chances to encounter the matching CD4+ T lymphocytes. Once CD4+ T cells have become acti- vated, they in turn trigger macrophages to eliminate pathogens that have been previously internalized, and B lymphocytes to produce pathogen- specific antibodies. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Class II MHC:Antigen | up-regulates activity
binding
|
CD4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267990 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31001252 |
Extracellular domain of CD4, which is responsible for the recognition of its ligands, is composed of four globular Ig-like domains (D1-D4). The N-terminal D1 domain binds to a segment of the non-polymorphic β2 domain of MHC class II. CD4 is required for the recognition of most antigens in vivo. The presence of the CD4 coreceptor enhances T cell sensitivity to antigens |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | T cell activation |
| + |
Class II MHC:Antigen | up-regulates
|
T_cell_activation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267873 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31810556 |
Once they are formed, peptide/MHC class II molecules complexes are very stable and allow for sustained antigen presentation increasing the chances to encounter the matching CD4+ T lymphocytes. Once CD4+ T cells have become acti- vated, they in turn trigger macrophages to eliminate pathogens that have been previously internalized, and B lymphocytes to produce pathogen- specific antibodies. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | T cell activation |
| + |
peptide antigen | form complex
binding
|
Class II MHC:Antigen |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267871 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33374673 |
The major histocompatibility complex (MHC) molecules, or human leukocyte antigens (HLA) in humans, bind these peptides to present them to T cells that recognise them with their surface T cell receptors (TCR). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
Class II MHC:Antigen