4.0
T cell activation
Pathway ID: SIGNOR-TCAView in NDEx
Description: (From Wikipedia) T cells utilise the Src family kinases in transmembrane signalling largely to phosphorylate tyrosines that are part of immunoreceptor tyrosine-based activation motifs (ITAM) in intracellular parts of CD3 and ζ chains. Early signaling steps implicate the kinases lck an Fyn and Zap70 and the phosphatase CD45 after TCR triggering: When a T-cell receptor is activated by contact with a peptide:MHC complex, CD45 dephosphorylates inhibitory tyrosine of membrane-localized Src family kinases Fyn and Lck, previously recruited and activated by CD4 or CD8 coreceptors. Activated Fyn and Lck phosphorylates ITAMs on the CD3 and ζ chains. This allows cytoplasmic kinases of the Syk family (ZAP-70) to bind to the ITAM and activated ZAP-70 phosphorylates tyrosines on the adaptor protein LAT, which then attracts PLC-γ.
Curated by: Gianni
Description: (From Wikipedia) T cells utilise the Src family kinases in transmembrane signalling largely to phosphorylate tyrosines that are part of immunoreceptor tyrosine-based activation motifs (ITAM) in intracellular parts of CD3 and ζ chains. Early signaling steps implicate the kinases lck an Fyn and Zap70 and the phosphatase CD45 after TCR triggering: When a T-cell receptor is activated by contact with a peptide:MHC complex, CD45 dephosphorylates inhibitory tyrosine of membrane-localized Src family kinases Fyn and Lck, previously recruited and activated by CD4 or CD8 coreceptors. Activated Fyn and Lck phosphorylates ITAMs on the CD3 and ζ chains. This allows cytoplasmic kinases of the Syk family (ZAP-70) to bind to the ITAM and activated ZAP-70 phosphorylates tyrosines on the adaptor protein LAT, which then attracts PLC-γ.
Curated by: Gianni
42 Seed Entities
Organism: 
|
Name | Primary ID |
|---|---|
| CALM1 | P0DP23 |
| CTTN | Q14247 |
| CD28 | P10747 |
| GRB2 | P62993 |
| T_cell_activation | SIGNOR-PH73 |
| ARP2/3 | SIGNOR-C146 |
| F-actin_assembly | SIGNOR-PH18 |
| LCP2 | Q13094 |
| PI3K | SIGNOR-C156 |
| NCK1 | P16333 |
| NFKBIA | P25963 |
| TCR | SIGNOR-C153 |
| IKK-complex | SIGNOR-C14 |
| BRAF | P15056 |
| NfKb-p65/p50 | SIGNOR-C13 |
| CSK | P41240 |
| Immune_response | SIGNOR-PH17 |
| calcium(2+) | CHEBI:29108 |
| CD4 | P01730 |
| PLCG1 | P19174 |
| ZAP70 | P43403 |
| ERK1/2 | SIGNOR-PF1 |
| SOS1 | Q07889 |
| AKT | SIGNOR-PF24 |
| 1,2-diacyl-sn-glycerol | CHEBI:17815 |
| PRKCA | P17252 |
| MEK1/2 | SIGNOR-PF25 |
| LAT | O43561 |
| PTPRC | P08575 |
| Class II MHC:Antigen | SIGNOR-C429 |
| CD3 | SIGNOR-C432 |
| PDPK1 | O15530 |
| NFATC1 | O95644 |
| Calcineurin | SIGNOR-C155 |
| LCK | P06239 |
| PIP3 | CHEBI:16618 |
| FYN | P06241 |
| AP1 | SIGNOR-C154 |
| CD8A | P01732 |
| PAK1 | Q13153 |
| HRAS | P01112 |
| Class I MHC:Antigen | SIGNOR-C426 |