| + |
MPO-ANCA | up-regulates 
|
Neutrophil_activation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270583 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 2161532 |
ANCA cause normal human neutrophils to undergo an oxidative burst and degranulate. Both ANCA phenotypes (i.e., cytoplasmic-pattern ANCA and myeloperoxidase-specific ANCA) induce neutrophil activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Blood Serum |
| + |
MPO-ANCA | up-regulates
|
ROS |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270590 |
|
|
in vitro |
|
| pmid |
sentence |
| 2161532 |
ANCA-induced release of ROS measured by chemiluminescence. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
| form complex 
binding
|
MPO-ANCA |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270595 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27464484 |
Although MPO-ANCAs of the IgA isotype are sometimes found in patients with IgA nephropathy or IgA vasculitis45, isotypes other than IgG have not been reported in patients with typical AAV, with the exception of a single patient with pauci-immune crescentic glomerulonephritis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MPO-ANCA | up-regulates quantity by expression 
oxidation
|
thiocyanate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270591 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9922160 |
Myeloperoxidase plays a fundamental role in oxidant production by neutrophils. The enzyme uses hydrogen peroxide to oxidize chloride (Cl-), bromide (Br-), iodide (I-), and the pseudohalide thiocyanate (SCN-) to their respective hypohalous acids.| Our results show that thiocyanate is an important substrate of myeloperoxidase in most environments and that hypothiocyanate is likely to contribute to leukocyte antimicrobial activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Blood Serum |
| + |
MPO-ANCA | up-regulates
|
superoxide |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270589 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 15972951 |
Anti-MPO IgG (250 μg/ml) induces significant superoxide anion production in TNF-α-primed peritoneal exudate cells from WT C57BL/6 mice (black bars) as compared to normal mouse IgG (250 μg/ml) or buffer alone. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Blood Serum |
| + |
MPO | up-regulates activity
binding
|
MPO-ANCA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270585 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15972951 |
Wegener's granulomatosis, microscopic polyangiitis, Churg-Strauss syndrome, and idiopathic pauci-immune necrotizing crescentic glomerulonephritis are associated with myeloperoxidase (MPO)-specific anti-neutrophil cytoplasmic autoantibodies (ANCAs). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Blood Serum |
| + |
TNF | up-regulates
|
MPO-ANCA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270588 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 15972951 |
Second, LPS-mediated aggravation of anti-MPO IgG-induced glomerulonephritis was attenuated, but not prevented, by pretreatment with neutralizing anti-TNF-α antibodies. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Blood Serum |
| + |
PAMPs | up-regulates quantity
|
MPO-ANCA |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270586 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15972951 |
In the early phase, LPS enhanced anti-MPO IgG-induced glomerular neutrophil accumulation. |using bacterial lipopolysaccharide (LPS) as the proinflammatory stimulus. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Blood Serum |
3.0
MPO-ANCA