| + |
EDVP | down-regulates quantity by destabilization 
polyubiquitination
|
KATNA1 |
0.316 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271793 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 19287380 |
EDVP-DYRK2 complex regulates Katanin p60 ubiquitination. Katanin p60 was polyubiquitinated in the presence of the intact DYRK2-EDVP, but its ubiquitination was severely reduced by the depletion of DYRK2, EDD, DDB1 or VPRBP (Fig. 3d). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
UBR5 | form complex 
binding
|
EDVP |
0.393 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271790 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 19287380 |
We named this E3 ligase complex containing EDD, DDB1 and VPRBP proteins as EDVP complex to distinguish it from the previously identified Cul4-Roc1-DDB1-VPRBP E3 ligase complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DYRK2 | up-regulates activity 
binding
|
EDVP |
0.459 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271792 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 19287380 |
DYRK2 functions as an adaptor in the EDVP E3 ligase complex. These experiments suggest that DYRK2 functions as a molecular assembler required for the specific recruitment of EDD to DDB1-VPRBP, thus forming a novel EDVP E3 ligase complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DDB1 | form complex
binding
|
EDVP |
0.393 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271791 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 19287380 |
We named this E3 ligase complex containing EDD, DDB1 and VPRBP proteins as EDVP complex to distinguish it from the previously identified Cul4-Roc1-DDB1-VPRBP E3 ligase complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DCAF1 | form complex
binding
|
EDVP |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271789 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 19287380 |
We named this E3 ligase complex containing EDD, DDB1 and VPRBP proteins as EDVP complex to distinguish it from the previously identified Cul4-Roc1-DDB1-VPRBP E3 ligase complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
EDVP