| + |
acetylcholine | up-regulates activity 
chemical activation
|
Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha6-beta4 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280884 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 25460185 |
Neuronal nicotinic acetylcholine receptors (nAChRs) are a heterogeneous family of pentameric ligand-gated cation channels that are expressed throughout the brain and involved in a wide range of physiological and pathophysiological processes. The nAChR subtypes share a common basic structure, but their biophysical and pharmacological properties depend on their subunit composition, which is therefore central to understanding their function in the nervous system and discovering new subtype selective drugs.The variety of subtypes in the mammalian nervous system, is mainly due to the diversity of the possible combinations of the eleven neuronal subunits (all but α8) expressed in this animal class. nAChR subtypes can be divided into two main classes: 1) αBgtx-sensitive subtypes which can be homomeric or heteromeric, and are made up of the α7, α9 and α10 subunits; and 2) αBtgx-insensitive receptors, which are heteromeric combinations of α2–6 and β2–4 subunits that bind nicotine with high affinity but not αBgtx (Fig. 1B) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
nicotine | up-regulates activity
chemical activation
|
Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha6-beta4 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280891 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 25460185 |
Neuronal nicotinic acetylcholine receptors (nAChRs) are a heterogeneous family of pentameric ligand-gated cation channels that are expressed throughout the brain and involved in a wide range of physiological and pathophysiological processes. The nAChR subtypes share a common basic structure, but their biophysical and pharmacological properties depend on their subunit composition, which is therefore central to understanding their function in the nervous system and discovering new subtype selective drugs.The variety of subtypes in the mammalian nervous system, is mainly due to the diversity of the possible combinations of the eleven neuronal subunits (all but α8) expressed in this animal class. nAChR subtypes can be divided into two main classes: 1) αBgtx-sensitive subtypes which can be homomeric or heteromeric, and are made up of the α7, α9 and α10 subunits; and 2) αBtgx-insensitive receptors, which are heteromeric combinations of α2–6 and β2–4 subunits that bind nicotine with high affinity but not αBgtx (Fig. 1B) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CHRNB4 | form complex 
binding
|
Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha6-beta4 |
0.534 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280869 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 25460185 |
Neuronal nicotinic acetylcholine receptors (nAChRs) are a heterogeneous family of pentameric ligand-gated cation channels that are expressed throughout the brain and involved in a wide range of physiological and pathophysiological processes. The nAChR subtypes share a common basic structure, but their biophysical and pharmacological properties depend on their subunit composition, which is therefore central to understanding their function in the nervous system and discovering new subtype selective drugs.The variety of subtypes in the mammalian nervous system, is mainly due to the diversity of the possible combinations of the eleven neuronal subunits (all but α8) expressed in this animal class. nAChR subtypes can be divided into two main classes: 1) αBgtx-sensitive subtypes which can be homomeric or heteromeric, and are made up of the α7, α9 and α10 subunits; and 2) αBtgx-insensitive receptors, which are heteromeric combinations of α2–6 and β2–4 subunits that bind nicotine with high affinity but not αBgtx (Fig. 1B) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CHRNA3 | form complex
binding
|
Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha6-beta4 |
0.49 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280870 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 25460185 |
Neuronal nicotinic acetylcholine receptors (nAChRs) are a heterogeneous family of pentameric ligand-gated cation channels that are expressed throughout the brain and involved in a wide range of physiological and pathophysiological processes. The nAChR subtypes share a common basic structure, but their biophysical and pharmacological properties depend on their subunit composition, which is therefore central to understanding their function in the nervous system and discovering new subtype selective drugs.The variety of subtypes in the mammalian nervous system, is mainly due to the diversity of the possible combinations of the eleven neuronal subunits (all but α8) expressed in this animal class. nAChR subtypes can be divided into two main classes: 1) αBgtx-sensitive subtypes which can be homomeric or heteromeric, and are made up of the α7, α9 and α10 subunits; and 2) αBtgx-insensitive receptors, which are heteromeric combinations of α2–6 and β2–4 subunits that bind nicotine with high affinity but not αBgtx (Fig. 1B) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CHRNA6 | form complex
binding
|
Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha6-beta4 |
0.449 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280871 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 25460185 |
Neuronal nicotinic acetylcholine receptors (nAChRs) are a heterogeneous family of pentameric ligand-gated cation channels that are expressed throughout the brain and involved in a wide range of physiological and pathophysiological processes. The nAChR subtypes share a common basic structure, but their biophysical and pharmacological properties depend on their subunit composition, which is therefore central to understanding their function in the nervous system and discovering new subtype selective drugs.The variety of subtypes in the mammalian nervous system, is mainly due to the diversity of the possible combinations of the eleven neuronal subunits (all but α8) expressed in this animal class. nAChR subtypes can be divided into two main classes: 1) αBgtx-sensitive subtypes which can be homomeric or heteromeric, and are made up of the α7, α9 and α10 subunits; and 2) αBtgx-insensitive receptors, which are heteromeric combinations of α2–6 and β2–4 subunits that bind nicotine with high affinity but not αBgtx (Fig. 1B) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha6-beta4