| + |
RNase H2 complex | up-regulates 
|
RNA_degradation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280895 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21245041 |
RNA/DNA hybrids form during many key cellular processes including DNA replication (1), transcription (2) and telomere elongation (3). Ribonuclease H (RNase H) endonucleases degrade the RNA strand of such RNA/DNA hybrids and therefore have a central importance in cellular physiology. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PCNA | up-regulates activity 
binding
|
RNase H2 complex |
0.515 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280896 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21245041 |
PCNA binding promotes RNase HII activity in a hinge-dependent manner. It enhances both cleavage of ribonucleotides misincorporated in DNA duplexes, and the comprehensive hydrolysis of RNA primers formed during Okazaki fragment maturation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RNASEH2A | form complex 
binding
|
RNase H2 complex |
0.968 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280897 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21177858 |
The eukaryotic RNase H2 heterotrimeric complex recognizes RNA/DNA hybrids and (5')RNA-DNA(3')/DNA junction hybrids as substrates with similar efficiency, whereas bacterial RNases H2 are highly specialized in the recognition of the (5')RNA-DNA(3') junction and very poorly cleave RNA/DNA hybrids in the presence of Mg(2+) ions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RNASEH2B | form complex
binding
|
RNase H2 complex |
0.968 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280898 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21177858 |
The eukaryotic RNase H2 heterotrimeric complex recognizes RNA/DNA hybrids and (5')RNA-DNA(3')/DNA junction hybrids as substrates with similar efficiency, whereas bacterial RNases H2 are highly specialized in the recognition of the (5')RNA-DNA(3') junction and very poorly cleave RNA/DNA hybrids in the presence of Mg(2+) ions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RNASEH2C | form complex
binding
|
RNase H2 complex |
0.962 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280899 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21177858 |
The eukaryotic RNase H2 heterotrimeric complex recognizes RNA/DNA hybrids and (5')RNA-DNA(3')/DNA junction hybrids as substrates with similar efficiency, whereas bacterial RNases H2 are highly specialized in the recognition of the (5')RNA-DNA(3') junction and very poorly cleave RNA/DNA hybrids in the presence of Mg(2+) ions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
RNase H2 complex
CPX-745