| + |
STAM | form complex 
binding
|
ESCRT-0 complex |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280928 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19278655 |
The human Hrs and STAM proteins comprise the ESCRT-0 complex, which sorts ubiquitinated cell surface receptors to lysosomes for degradation. Here we report a model for the complete ESCRT-0 complex based on the crystal structure of the Hrs-STAM core complex, previously solved domain structures, hydrodynamic measurements, and Monte Carlo simulations. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HGS | form complex
binding
|
ESCRT-0 complex |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280929 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19278655 |
The human Hrs and STAM proteins comprise the ESCRT-0 complex, which sorts ubiquitinated cell surface receptors to lysosomes for degradation. Here we report a model for the complete ESCRT-0 complex based on the crystal structure of the Hrs-STAM core complex, previously solved domain structures, hydrodynamic measurements, and Monte Carlo simulations. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Early Endosome | up-regulates quantity 
binding
|
ESCRT-0 complex |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280930 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22361144 |
The ESCRT-0 complex initiates the MVB pathway. It is the first complex of the ESCRT machinery that localizes to endosomes and does so via an interaction with an endosome-enriched phospholipid, phosphatidylinositol-3-phosphate (PI3P) (Figure 2). On endosomes, ESCRT-0 binds to ubiquitin moieties that are attached to membrane proteins destined for degradation, and thus executes the first sorting step in the MVB pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ESCRT-0 complex | up-regulates quantity
binding
|
ESCRT-I complex, VPS37A-UBAP1 variant |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280931 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22361144 |
ESCRT-I is a soluble hetero-tetramer consisting of Vps23/TSG101, Vps28, Vps37(A–D) and Mvb12(A,B) or ubiquitin-associated protein 1 (UBAP1) (Figure 2). Its efficient recruitment from the cytoplasm to endosomes requires protein–protein interactions with the ESCRT-0 complex. UBAP1-containing ESCRT-I appears to be more specific for MVB sorting, whereas Mvb12A/B-containing ESCRT-I also functions during HIV budding. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
ESCRT-0 complex