| + |
SWI5 | form complex 
binding
|
SWI5-SFR1 recombination accessory factor complex |
0.788 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281380 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21252223 |
Here, we identify and characterize the human SWI5-MEI5 (C9orf119-C10orf78) complex. We showed that SWI5 and MEI5 form a stable complex in vitro and in vivo. The C-terminal Swi5 domain of SWI5 and the middle coiled-coil region of MEI5 dictate this conserved interaction. In addition, SWI5-MEI5 directly interacts with RAD51 in vitro. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SFR1 | form complex
binding
|
SWI5-SFR1 recombination accessory factor complex |
0.788 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281381 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21252223 |
Here, we identify and characterize the human SWI5-MEI5 (C9orf119-C10orf78) complex. We showed that SWI5 and MEI5 form a stable complex in vitro and in vivo. The C-terminal Swi5 domain of SWI5 and the middle coiled-coil region of MEI5 dictate this conserved interaction. In addition, SWI5-MEI5 directly interacts with RAD51 in vitro. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SWI5-SFR1 recombination accessory factor complex | up-regulates activity 
binding
|
RAD51 |
0.518 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281382 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21252223 |
In this study, we report the identification and characterization of the human SWI5-MEI5 complex. This complex directly binds to RAD51 and promotes RAD51 focus formation following DNA damage. Together, these data support that SWI5-MEI5 is another mediator involved in homologous recombination repair in humans. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
SWI5-SFR1 recombination accessory factor complex