| + |
lipopolysaccharide | up-regulates activity
binding
|
TLR2-TLR10 toll-like receptor complex |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281411 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34180006 |
TLR10 may heterodimerize with TLR2 to recognize LPS and heat shock proteins (HSP60) of Helicobacter pylori (H. pylori) to trigger innate immune responses. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TLR2 | form complex
binding
|
TLR2-TLR10 toll-like receptor complex |
0.377 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281406 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34180006 |
TLR10, another member of the TLR2 subfamily, has high structural homology with TLR1 and TLR6. It can homo-dimerize or heterodimerize with TLR1 and TLR2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TLR10 | form complex
binding
|
TLR2-TLR10 toll-like receptor complex |
0.377 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281407 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34180006 |
TLR10, another member of the TLR2 subfamily, has high structural homology with TLR1 and TLR6. It can homo-dimerize or heterodimerize with TLR1 and TLR2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TLR2-TLR10 toll-like receptor complex | up-regulates quantity by stabilization
binding
|
IKBKB |
0.471 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281409 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34180006 |
TLR10 is the only TLR that can antagonize TLR2 activity, inhibit downstream signal transductions, and suppress B cell adaptive immune responses (Hess et al. 2017; Oosting et al. 2014; Su et al. 2020). It acts as a negative regulator of both MyD88 and TRIF-mediated signaling, suppressing the degradation of IκB and the phosphorylation of MAPKs through the production of IFN-β (Jiang et al. 2016). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |