| + |
RIC1 | form complex 
binding
|
RIC1-RGP1 guanyl-nucleotide exchange factor complex |
0.757 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281513 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23091056 |
Ric1-Rgp1 complex is a guanine nucleotide exchange factor for the late Golgi Rab6A GTPase and an effector of the medial Golgi Rab33B GTPase |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RGP1 | form complex
binding
|
RIC1-RGP1 guanyl-nucleotide exchange factor complex |
0.757 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281514 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23091056 |
Ric1-Rgp1 complex is a guanine nucleotide exchange factor for the late Golgi Rab6A GTPase and an effector of the medial Golgi Rab33B GTPase |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RIC1-RGP1 guanyl-nucleotide exchange factor complex | up-regulates activity 
guanine nucleotide exchange factor
|
RAB6A |
0.644 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281515 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23091056 |
Ric1-Rgp1 complex is a guanine nucleotide exchange factor for the late Golgi Rab6A GTPase and an effector of the medial Golgi Rab33B GTPase |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAB33B | up-regulates activity
binding
|
RIC1-RGP1 guanyl-nucleotide exchange factor complex |
0.542 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281516 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23091056 |
Ric1-Rgp1 complex is a guanine nucleotide exchange factor for the late Golgi Rab6A GTPase and an effector of the medial Golgi Rab33B GTPase. In addition, we have shown that Ric1 and Rgp1 can each bind Rab6A-GDP independently; at least Ric1 can also bind Rab33B-GTP directly, to form a possible Rab cascade at the Golgi. Binding of Rab33B did not compete with binding for Rab6A, consistent with the proteins occupying a distinct binding site on Ric1 protein. Thus, we have identified four distinct domains in Ric1: an N-terminal, putative β propeller followed by independent binding sites for Rgp1, Rab6A-GDP, and Rab33B-GTP |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
RIC1-RGP1 guanyl-nucleotide exchange factor complex