| + |
MLL/SET subcomplex | form complex 
binding
|
MLL1 complex |
0.785 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-204819 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24680668 |
The mixed lineage leukemia-1 (mll1) enzyme is a histone h3 lysine 4 (h3k4) monomethyltransferase and has served as a paradigm for understanding the mechanism of action of the human set1 family of enzymes that include mll1_Mll4 and setd1a,b. Dimethylation of h3k4 requires a sub-complex including wrad (wdr5, rbbp5, ash2l, and dpy-30), which binds to each set1 family member forming a minimal core complex that is required for multiple lysine methylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RBBP5 | form complex
binding
|
MLL/SET subcomplex |
0.908 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-204825 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24680668 |
Dimethylation of h3k4 requires a sub-complexincluding wrad (wdr5, rbbp5, ash2l, and dpy-30), which binds to each set1 family member forming a minimal corecomplexthat is required for multiple lysine methylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MLL/SET subcomplex | form complex
binding
|
MLL2 complex |
0.802 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-204822 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24680668 |
The mixed lineage leukemia-1 (mll1) enzyme is a histone h3 lysine 4 (h3k4) monomethyltransferase and has served as a paradigm for understanding the mechanism of action of the human set1 family of enzymes that include mll1_Mll4 and setd1a,b. Dimethylation of h3k4 requires a sub-complex including wrad (wdr5, rbbp5, ash2l, and dpy-30), which binds to each set1 family member forming a minimal core complex that is required for multiple lysine methylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DPY30 | form complex
binding
|
MLL/SET subcomplex |
0.893 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-204747 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24680668 |
Dimethylation of h3k4 requires a sub-complexincluding wrad (wdr5, rbbp5, ash2l, and dpy-30), which binds to each set1 family member forming a minimal corecomplexthat is required for multiple lysine methylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CHD8 | up-regulates activity 
binding
|
MLL/SET subcomplex |
0.431 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268807 |
|
|
Homo sapiens |
NT2/D1 Cell |
| pmid |
sentence |
| 20085832 |
Chromodomain, helicase, DNA-binding protein 8 (CHD8) is an ATP-dependent chromatin remodeling enzyme that has been demonstrated to exist within a large protein complex which includes WDR5, Ash2L, and RbBP5, members of the Mixed Lineage Leukemia (MLL) histone modifying complexes. CHD8 forms a complex with the core WDR5/Ash2L/RbBP5 complex. CHD8 is required for recruitment of the WAR complex |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Set1-Ash2 HMT complex | form complex
binding
|
MLL/SET subcomplex |
0.846 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-204744 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24680668 |
Dimethylation of h3k4 requires a sub-complexincluding wrad (wdr5, rbbp5, ash2l, and dpy-30), which binds to each set1 family member forming a minimal corecomplexthat is required for multiple lysine methylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MLL/SET subcomplex | form complex
binding
|
MLL3 complex |
0.748 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268808 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34156443 |
MLL3/KMT2C and MLL4/KMT2D are two paralogous histone modifiers that belong to the SET1/MLL (also named COMPASS) family of lysine methyltransferases and play critical roles in enhancer-regulated gene activation. MLL3 and MLL4 form identical multi-protein complexes for modifying mono-methylation of histone H3 lysine 4 (H3K4) at enhancers, which together with the p300/CBP-mediated H3K27 acetylation can generate an active enhancer landscape for long-range target gene activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SETD1B | form complex
binding
|
MLL/SET subcomplex |
0.901 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268796 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24680668 |
Dimethylation of h3k4 requires a sub-complex including wrad (wdr5, rbbp5, ash2l, and dpy-30), which binds to each set1 family member forming a minimal corecomplexthat is required for multiple lysine methylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
MLL/SET subcomplex