| + |
MLL1 complex | down-regulates activity 
methylation
|
H3-4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268803 |
Lys5 |
kQTARKST |
Homo sapiens |
|
| pmid |
sentence |
| 24680668 |
Dimethylation of h3k4 requires a sub-complex including wrad (wdr5, rbbp5, ash2l, and dpy-30), which binds to each set1 family member forming a minimal corecomplexthat is required for multiple lysine methylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MLL1 complex | down-regulates activity
methylation
|
H3-3A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268802 |
Lys5 |
kQTARKST |
Homo sapiens |
|
| pmid |
sentence |
| 24680668 |
Dimethylation of h3k4 requires a sub-complex including wrad (wdr5, rbbp5, ash2l, and dpy-30), which binds to each set1 family member forming a minimal corecomplexthat is required for multiple lysine methylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MLL1 complex | down-regulates activity
methylation
|
H3C1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268801 |
Lys5 |
kQTARKST |
Homo sapiens |
|
| pmid |
sentence |
| 24680668 |
Dimethylation of h3k4 requires a sub-complex including wrad (wdr5, rbbp5, ash2l, and dpy-30), which binds to each set1 family member forming a minimal corecomplexthat is required for multiple lysine methylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KMT2A | form complex 
binding
|
MLL1 complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-204813 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24680668 |
The mixed lineage leukemia-1 (mll1) enzyme is a histone h3 lysine 4 (h3k4) monomethyltransferase and has served as a paradigm for understanding the mechanism of action of the human set1 family of enzymes that include mll1_Mll4 and setd1a,b. Dimethylation of h3k4 requires a sub-complex including wrad (wdr5, rbbp5, ash2l, and dpy-30), which binds to each set1 family member forming a minimal core complex that is required for multiple lysine methylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PAX7 | up-regulates 
binding
|
MLL1 complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217716 |
|
|
Homo sapiens |
Satellite Cell |
| pmid |
sentence |
| 22863532 |
Carm1 specifically methylates multiple arginines in the n-terminus of pax7. Methylated pax7 directly binds the c-terminal cleavage forms of the trithorax proteins mll1/2 resulting in the recruitment of the ash2l:mll1/2:wdr5:rbbp5 histone h3k4 methyltransferase complex to regulatory enhancers and the proximal promoter of myf5. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
| + |
MLL/SET subcomplex | form complex
binding
|
MLL1 complex |
0.784 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-204819 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24680668 |
The mixed lineage leukemia-1 (mll1) enzyme is a histone h3 lysine 4 (h3k4) monomethyltransferase and has served as a paradigm for understanding the mechanism of action of the human set1 family of enzymes that include mll1_Mll4 and setd1a,b. Dimethylation of h3k4 requires a sub-complex including wrad (wdr5, rbbp5, ash2l, and dpy-30), which binds to each set1 family member forming a minimal core complex that is required for multiple lysine methylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MLL1 complex | form complex
binding
|
PAX7/MLL1 complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198620 |
|
|
Homo sapiens |
Satellite Cell |
| pmid |
sentence |
| 22863532 |
Carm1 specifically methylates multiple arginines in the n-terminus of pax7. Methylated pax7 directly binds the c-terminal cleavage forms of the trithorax proteins mll1/2 resulting in the recruitment of the ash2l:mll1/2:wdr5:rbbp5 histone h3k4 methyltransferase complex to regulatory enhancers and the proximal promoter of myf5. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
3.0
MLL1 complex