Relation Results

Summary

Name MLL2 complex
Primary ID SIGNOR-C88
Type complex
Formed by KMT2D, MLL/SET subcomplex
Relations 10

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Type: Score: Layout: SPV 
0.20.20.20.20.8140.4560.20.20.3060.2MLL2 complexH3C1H3-3AH3-4PAX7/MLL2 complexKDM6AESR1CBP/p300MLL/SET subcomplexPAX7KMT2D

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ MLL2 complexdown-regulates activity img/direct_inhibition.png methylation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268798 Lys5 kQTARKST Homo sapiens
pmid sentence
Dimethylation of h3k4 requires a sub-complex including wrad (wdr5, rbbp5, ash2l, and dpy-30), which binds to each set1 family member forming a minimal corecomplexthat is required for multiple lysine methylation.
Publications: 1 Organism: Homo Sapiens
+ MLL2 complexdown-regulates activity img/direct_inhibition.png methylation H3-3A 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268799 Lys5 kQTARKST Homo sapiens
pmid sentence
Dimethylation of h3k4 requires a sub-complex including wrad (wdr5, rbbp5, ash2l, and dpy-30), which binds to each set1 family member forming a minimal corecomplexthat is required for multiple lysine methylation.
Publications: 1 Organism: Homo Sapiens
+ MLL2 complexdown-regulates activity img/direct_inhibition.png methylation H3-4 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268800 Lys5 kQTARKST Homo sapiens
pmid sentence
Dimethylation of h3k4 requires a sub-complex including wrad (wdr5, rbbp5, ash2l, and dpy-30), which binds to each set1 family member forming a minimal corecomplexthat is required for multiple lysine methylation.
Publications: 1 Organism: Homo Sapiens
+ MLL2 complexform complex img/form-complex.png binding PAX7/MLL2 complex 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-198623 Homo sapiens Satellite Cell
pmid sentence
Carm1 specifically methylates multiple arginines in the n-terminus of pax7. Methylated pax7 directly binds the c-terminal cleavage forms of the trithorax proteins mll1/2 resulting in the recruitment of the ash2l:mll1/2:wdr5:rbbp5 histone h3k4 methyltransferase complex to regulatory enhancers and the proximal promoter of myf5.
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ MLL2 complexup-regulates quantity by stabilization img/direct-activation.png binding KDM6A 0.814
Identifier Residue Sequence Organism Cell Line
SIGNOR-268813 Homo sapiens
pmid sentence
KMT2D associates with WRAD (WDR5, RbBP5, ASH2L, and DPY30), NCOA6, PTIP, PA1, and H3K27 demethylase UTX in one protein complex. It acts as a scaffold protein within the complex and is responsible for maintaining the stability of UTX. UTX is the complex’s H3K27 demethylase.
Publications: 1 Organism: Homo Sapiens
+ MLL2 complexup-regulates img/direct-activation.png binding ESR1 0.456
Identifier Residue Sequence Organism Cell Line
SIGNOR-145868 Homo sapiens
pmid sentence
Eralpha directly binds to the mll2 complex through two lxxll motifs in a region of mll2 near the c terminus in a ligand-dependent manner. Disrupting the interaction between eralpha and the mll2 complex with small interfering rnas specific against mll2 or an mll2 fragment representing the interacting region with eralpha significantly inhibited the eralpha transcription activity.
Publications: 1 Organism: Homo Sapiens
+ MLL2 complexup-regulates activity img/direct-activation.png binding CBP/p300 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268814 Homo sapiens
pmid sentence
KMT2D associates with WRAD (WDR5, RbBP5, ASH2L, and DPY30), NCOA6, PTIP, PA1, and H3K27 demethylase UTX in one protein complex. It acts as a scaffold protein within the complex and is responsible for maintaining the stability of UTX. KMT2D is a major mammalian H3K4 mono-methyltransferase and co-localizes with lineage determining transcription factors on transcriptional enhancers. It is required for the binding of histone H3K27 acetyltransferases CBP and p300 on enhancers, enhancer activation and cell-type specific gene expression during differentiation.
Publications: 1 Organism: Homo Sapiens
+ MLL/SET subcomplexform complex img/form-complex.png binding MLL2 complex 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-204822 Homo sapiens
pmid sentence
The mixed lineage leukemia-1 (mll1) enzyme is a histone h3 lysine 4 (h3k4) monomethyltransferase and has served as a paradigm for understanding the mechanism of action of the human set1 family of enzymes that include mll1_Mll4 and setd1a,b. Dimethylation of h3k4 requires a sub-complex including wrad (wdr5, rbbp5, ash2l, and dpy-30), which binds to each set1 family member forming a minimal core complex that is required for multiple lysine methylation.
Publications: 1 Organism: Homo Sapiens
+ PAX7up-regulates img/direct-activation.png binding MLL2 complex 0.306
Identifier Residue Sequence Organism Cell Line
SIGNOR-217712 Homo sapiens Satellite Cell
pmid sentence
Carm1 specifically methylates multiple arginines in the n-terminus of pax7. Methylated pax7 directly binds the c-terminal cleavage forms of the trithorax proteins mll1/2 resulting in the recruitment of the ash2l:mll1/2:wdr5:rbbp5 histone h3k4 methyltransferase complex to regulatory enhancers and the proximal promoter of myf5.
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ KMT2Dform complex img/form-complex.png binding MLL2 complex 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-204816 Homo sapiens
pmid sentence
The mixed lineage leukemia-1 (mll1) enzyme is a histone h3 lysine 4 (h3k4) monomethyltransferase and has served as a paradigm for understanding the mechanism of action of the human set1 family of enzymes that include mll1_Mll4 and setd1a,b. Dimethylation of h3k4 requires a sub-complex including wrad (wdr5, rbbp5, ash2l, and dpy-30), which binds to each set1 family member forming a minimal core complex that is required for multiple lysine methylation.
Publications: 1 Organism: Homo Sapiens
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