| + |
HACD | up-regulates activity 
binding
|
ELOVL |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267915 |
|
|
|
|
| pmid |
sentence |
| 18554506 |
Very long-chain fatty acids are produced through a four-step cycle. Mammals have four candidates, HACD1-4, based on sequence similarities to the recently identified yeast Phs1, although HACD3 and HACD4 share relatively weak similarity. We demonstrate that all four of these human proteins are indeed 3-hydroxyacyl-CoA dehydratases.We also established that the HACD proteins interact with ELOVL proteins. Our analyses have completed the identification of mammalian enzymes responsible for the entire VLCFA elongation cycle. |
|
| Publications: |
1 |
| Pathways: | Fatty Acid Synthesis |
| + |
SREBF1 | up-regulates quantity by expression
transcriptional regulation
|
ELOVL |
0.473 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267944 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 18226595 |
These data demonstrated that Elovl-6 is regulated directly and primarily by SREBP-1c. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ELOVL | down-regulates quantity 
chemical modification
|
palmitoyl-CoA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267901 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31616255 |
The ELOVL family of enzymes in mammals is comprised of seven members that all reside in the endoplasmic reticulum (ER) and are thought to form a multimeric complex. Together, the ELOVL family is responsible for the elongation of saturated and unsaturated fatty acids.Fatty acid elongation occurs by cycling through a four step process (condensation, reduction, dehydration, and reduction), with two carbon atoms added through each cycle. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Fatty Acid Synthesis |
| + |
ELOVL | up-regulates quantity
chemical modification
|
3-hydroxyoctadecanoyl-CoA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267902 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31616255 |
The ELOVL family of enzymes in mammals is comprised of seven members that all reside in the endoplasmic reticulum (ER) and are thought to form a multimeric complex. Together, the ELOVL family is responsible for the elongation of saturated and unsaturated fatty acids.Fatty acid elongation occurs by cycling through a four step process (condensation, reduction, dehydration, and reduction), with two carbon atoms added through each cycle. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Fatty Acid Synthesis |
3.0
ELOVL