| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259915 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30886364 |
In humans, the thyroid hormones T3 and T4 are synthesized in the thyroid gland in a process that crucially involves the iodoglycoprotein thyroglobulin. The overall structure of thyroglobulin is conserved in all vertebrates. Upon thyroglobulin delivery from thyrocytes to the follicular lumen of the thyroid gland via the secretory pathway, multiple tyrosine residues can become iodinated to form mono-iodotyrosine (MIT) and/or di-iodotyrosine (DIT); however, selective tyrosine residues lead to preferential formation of T4 and T3 at distinct sites. |
|
3.0
Thyroid_hormonogenesis
