| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263225 |
|
|
|
|
| pmid |
sentence |
| 25400280 |
Another BRCA1 complex, the BRCA1–B complex containing BRCA1/TopBP1 and BACH1 (also known and BRIP1/FANCJ) has been reported to play a role in HR and S‐phase cell cycle arrest. The exact role of this complex in HR remains unclear, although it is assumed that BACH1, a DNA helicase, contributes to end resection (possibly through its helicase activity) and RPA loading, whereas TopBP1 is required for ATR activation and subsequent S‐phase checkpoint activation |
|
3.0
G1/S_transition_checkpoint
