| + |
TERT | up-regulates 
|
Telomere_maintenance |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263334 |
|
|
|
|
| pmid |
sentence |
| 18680434 |
Dyskerin was recently found to be associated with active human telomerase (34), and mutations in dyskerin or NOP10 or deletion of the H/ACA motif of hTERC result in diminished telomerase activity |
|
| Publications: |
1 |
| + |
TPP1 | up-regulates 
|
Telomere_maintenance |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272723 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22101936 |
The mammalian shelterin component TPP1 has essential roles in telomere maintenance and, together with POT1, is required for the repression of DNA damage signaling at telomeres. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Shelterin complex | up-regulates
|
Telomere_maintenance |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263309 |
|
|
|
|
| pmid |
sentence |
| 33015044 |
The shelterin complex has six proteins, containing TRF1, TRF2, POT1, RAP1, TIN2, and TPP1. The shelterin complex is localized to the chromosome end and protects telomeric DNA (Palm and de Lange, 2008). The TTM complex acts as a “linker” and bridges the LINC and shelterin complexes together. The connection between TTM and shelterin complexes is well-known, which is mediated by TERB1 and TRF1 |
|
| Publications: |
1 |
| + |
RINT1 | down-regulates 
|
Telomere_maintenance |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265031 |
|
|
Homo sapiens |
HFF-1 Cell |
| pmid |
sentence |
| 16600870 |
We propose that p130, forming a complex with Rad50 through RINT-1, blocks telomerase-independent telomere lengthening in normal cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
Telomere_maintenance