| + |
MSN | up-regulates 
|
Platelet_aggregation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268434 |
|
|
Homo sapiens |
Blood Platelet |
| pmid |
sentence |
| 35267019 |
Rev-erbα interacted with OPHN-1, promoted RhoA activity and phosphorylation of ERM. etection of phosphorylated ezrin (Thr567)/radixin (Thr564)/moesin (Thr558)(p-ERM) in Rev-erbαfl/flCre− and Rev-erbαfl/flPF4Cre+ platelets using phospho-specific antibodies. Taken together, these results suggest that Rev-erbα potentiates platelet activation via an OPHN-1-mediated RhoA/ERM signalling pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FGA | up-regulates
|
Platelet_aggregation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253372 |
|
|
|
|
| pmid |
sentence |
| 16418530 |
In response to agonist stimulation, the αIIbβ3 integrin on platelets is converted to an active conformation that binds fibrinogen and mediates platelet aggregation. |
|
| Publications: |
1 |
| + |
FGB | up-regulates
|
Platelet_aggregation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253374 |
|
|
|
|
| pmid |
sentence |
| 16418530 |
In response to agonist stimulation, the αIIbβ3 integrin on platelets is converted to an active conformation that binds fibrinogen and mediates platelet aggregation. |
|
| Publications: |
1 |
| + |
AIIB/b3 integrin | up-regulates
|
Platelet_aggregation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266067 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 18278053 |
Activated alphaIIbbeta3 integrins bind fibrinogen, vWF and fibronectin, thus allowing firm platelet adhesion and platelet aggregation. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
EZR | up-regulates
|
Platelet_aggregation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268432 |
|
|
Homo sapiens |
Blood Platelet |
| pmid |
sentence |
| 35267019 |
Rev-erbα interacted with OPHN-1, promoted RhoA activity and phosphorylation of ERM. etection of phosphorylated ezrin (Thr567)/radixin (Thr564)/moesin (Thr558)(p-ERM) in Rev-erbαfl/flCre− and Rev-erbαfl/flPF4Cre+ platelets using phospho-specific antibodies. Taken together, these results suggest that Rev-erbα potentiates platelet activation via an OPHN-1-mediated RhoA/ERM signalling pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FGG | up-regulates
|
Platelet_aggregation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253373 |
|
|
|
|
| pmid |
sentence |
| 16418530 |
In response to agonist stimulation, the αIIbβ3 integrin on platelets is converted to an active conformation that binds fibrinogen and mediates platelet aggregation. |
|
| Publications: |
1 |
| + |
GPIb-IX-V complex | up-regulates
|
Platelet_aggregation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261866 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32644488 |
Therefore, VWF cannot bind to the GpIb receptors on platelets via the A1 domain to induce platelet aggregation and further hemostasis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RDX | up-regulates
|
Platelet_aggregation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268433 |
|
|
Homo sapiens |
Blood Platelet |
| pmid |
sentence |
| 35267019 |
Rev-erbα interacted with OPHN-1, promoted RhoA activity and phosphorylation of ERM. etection of phosphorylated ezrin (Thr567)/radixin (Thr564)/moesin (Thr558)(p-ERM) in Rev-erbαfl/flCre− and Rev-erbαfl/flPF4Cre+ platelets using phospho-specific antibodies. Taken together, these results suggest that Rev-erbα potentiates platelet activation via an OPHN-1-mediated RhoA/ERM signalling pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CHEVI complex | up-regulates
|
Platelet_aggregation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261833 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27319744 |
VPS33B association with VIPAS39, α-tubulin, and SEC22B was identified by co-immunoprecipitation, mass spectra, and immunoblotting in human embryonic kidney 293T (HEK293T) cells. Also, pull-down experiments revealed that VIPAS39 bound to intact VPS33B; in contrast, α-tubulin and SEC22B separately interacted with the sec1-like domains of VPS33B. Vps33b deficiency in megakaryocytes disturbs the redistribution of Vipas39 and Sec22b to proplatelets, and interrupted the co-localization of Sec22b with Vwf-positive vesicles |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
Platelet_aggregation