| + |
ESCRT-III | up-regulates 
|
Multivesicular_body_assembly |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280934 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22361144 |
In vivo and in vitro data suggest a key role for the ESCRT-III complex in all ESCRT-mediated membrane remodeling (budding and scission) reactions, although the mechanism is not understood. Hence, ESCRT-III filaments may have a dual role during MVB sorting: cargo sequestration within the site of MVB vesicle formation and membrane budding/scission. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ESCRT-I complex, VPS37A-UBAP1 variant | up-regulates
|
Multivesicular_body_assembly |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280935 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22361144 |
In vivo and in vitro data suggest a key role for the ESCRT-III complex in all ESCRT-mediated membrane remodeling (budding and scission) reactions, although the mechanism is not understood. Hence, ESCRT-III filaments may have a dual role during MVB sorting: cargo sequestration within the site of MVB vesicle formation and membrane budding/scission. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ESCRT-II complex | up-regulates
|
Multivesicular_body_assembly |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280936 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22361144 |
In vivo and in vitro data suggest a key role for the ESCRT-III complex in all ESCRT-mediated membrane remodeling (budding and scission) reactions, although the mechanism is not understood. Hence, ESCRT-III filaments may have a dual role during MVB sorting: cargo sequestration within the site of MVB vesicle formation and membrane budding/scission. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PAS complex | up-regulates
|
Multivesicular_body_assembly |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253532 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17556371 |
Sac3 assembles with PIKfyve and ArPIKfyve in a stable ternary complex and controls PtdIns(3,5)P2 levels. We further demonstrate a key function for each of the three proteins in the biogenesis of ECV/MVB transport intermediates from early endosomes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
Multivesicular_body_assembly