| + |
Hypoxia | up-regulates 
|
HIF-1 complex |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267449 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27692180 |
Hypoxia-Inducible Factor-1 (HIF-1) is a key transcription factor that regulates gene expression under hypoxic conditions (Semenza, 2012, 2010a). HIF-1 consists of two subunits, HIF-1α and HIF-1β. While HIF-1β protein is constitutively expressed and present in excess, HIF-1α protein has a short half-life |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Hypoxia | down-regulates 
|
EGLN2 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262001 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24990963 |
There are three EglN family members in humans and mice (EglN1, EglN2, and EglN3). Their enzymatic activity requires oxygen, ascorbic acid, iron, and α-ketoglutarate (α-KG). Under hypoxic conditions, EglNs lose their activity and fail to hydroxylate HIFα, which leads to HIFα stabilization |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Hypoxia | down-regulates
|
EGLN1 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261995 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32755251 |
Under hypoxic conditions, PHD2 activity is limited, and therefore HIF-1α protein is stabilized, leading to an increase in the transcription of erythropoietin as well as hundreds of target genes that coordinate diverse processes |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Hypoxia | up-regulates
|
NPTX1 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261431 |
|
|
Mus musculus |
Neuron |
| pmid |
sentence |
| 15115814 |
We found that NP1 colocalizes and physically associates with the fast excitatory GluR1 AMPA receptors and that hypoxia induces a time-dependent increase in the NP1-GluR1 interactions. Thus hypoxia recruits NP1 protein to GluR1 subunits concurrent with the hypoxic excitotoxic cascade.|Rather we propose that through interactions with GluR1 clusters, NP1 modulates the function of AMPA receptors in a manner whereby increased NP1-GluR1 interactions sensitize neurons to hypoxia-induced excitotoxic death. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
Hypoxia | down-regulates
|
EGLN3 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262002 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24990963 |
There are three EglN family members in humans and mice (EglN1, EglN2, and EglN3). Their enzymatic activity requires oxygen, ascorbic acid, iron, and α-ketoglutarate (α-KG). Under hypoxic conditions, EglNs lose their activity and fail to hydroxylate HIFα, which leads to HIFα stabilization |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Hypoxia | up-regulates
|
KDM4B |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263735 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30759871 |
The KDM4 family of Jumonj domain histone demethylases specifically target di- and tri-methylated lysine 9 on histone H3 (H3K9me3), removing a modification central to defining heterochromatin and gene repression. KDM4 enzymes are generally over-expressed in cancers, making them compelling targets for study and therapeutic inhibition. One of these family members, KDM4B, is especially interesting due to its regulation by multiple cellular stimuli, including DNA damage, steroid hormones, and hypoxia. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
Hypoxia