| + |
miR-429 | down-regulates quantity by destabilization 
post transcriptional regulation
|
ZEB2 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281199 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18376396 |
On the basis of the preceding observations, we surmised that a function of miR-205 and the miR-200 family is to prevent expression of ZEB1 and SIP1 in epithelial cells, which may otherwise trigger EMT by downregulating E-cadherin, and further, that downregulation of the microRNAs may be sufficient to initiate EMT. To test this, we examined the effect of the microRNA inhibitors on cell phenotype.We found that all five members of the microRNA-200 family (miR-200a, miR-200b, miR-200c, miR-141 and miR-429) and miR-205 were markedly downregulated in cells that had undergone EMT in response to transforming growth factor (TGF)-β or to ectopic expression of the protein tyrosine phosphatase Pez.Together, these microRNAs cooperatively regulate expression of the E-cadherin transcriptional repressors ZEB1 (also known as δEF1) and SIP1 (also known as ZEB2), factors previously implicated in EMT and tumour metastasis. |
|
| + |
miR-429 | down-regulates quantity by destabilization
post transcriptional regulation
|
ZEB1 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281200 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18376396 |
On the basis of the preceding observations, we surmised that a function of miR-205 and the miR-200 family is to prevent expression of ZEB1 and SIP1 in epithelial cells, which may otherwise trigger EMT by downregulating E-cadherin, and further, that downregulation of the microRNAs may be sufficient to initiate EMT. To test this, we examined the effect of the microRNA inhibitors on cell phenotype.We found that all five members of the microRNA-200 family (miR-200a, miR-200b, miR-200c, miR-141 and miR-429) and miR-205 were markedly downregulated in cells that had undergone EMT in response to transforming growth factor (TGF)-β or to ectopic expression of the protein tyrosine phosphatase Pez.Together, these microRNAs cooperatively regulate expression of the E-cadherin transcriptional repressors ZEB1 (also known as δEF1) and SIP1 (also known as ZEB2), factors previously implicated in EMT and tumour metastasis. |
|
4.0
miR-429
