SAPK/JNK Signaling

Pathway ID: SIGNOR-SAPK-JNKView in NDEx

Description: Stress-activated protein kinases/c-Jun NH(2)-terminal kinases (SAPK/JNK) proteins are MAPK family members that are activated by several extracellular signals (i.e. inflammatory cytokines and growth factors) and cellular stress. When activated by cellular stress the SAPK/JNK pathway induces cell death by apoptosis. The SAPK/JNK pathway also plays a physiological role in embryonic development by regulating cell survival, apoptosis, and proliferation.

Curated by: Daniela Posca

complexity level

level 1 seed interactions
level 2 connect
level 3 first neighbors
level 4 all
level 5 PPI

24 Seed Entities

Organism:
Name Primary ID
883065-90-5 CID:2747117
ATF2 P15336
BAX Q07812
BCL2L11 O43521
CRK P46108
ELK1 P19419
GRB2 P62993
JUN P05412
MAP2K4 P45985
MAP2K6 P52564
MAP3K1 Q13233
MAP3K7 O43318
MAP4K1 Q92918
MAP4K2 Q12851
MAPK8 P45983
MAPK8IP1 Q9UQF2
NFATC2 Q13469
RIPK1 Q13546
SH3RF1 Q7Z6J0
SMAD3 P84022
TNFRSF1B P20333
TRAF1 Q13077
TRAF2 Q12933
YWHAZ P63104