Summary

Name ARHGAP10
Full Name Rho GTPase-activating protein 10
Synonyms GTPase regulator associated with focal adhesion kinase 2, Graf-related protein 2, Rho-type GTPase-activating protein 10 | GRAF2
Primary ID A1A4S6
Links - -
Type protein
Relations 1
Function GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity).

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Relations

Regulator Mechanism target score ℹ
+ ARHGAP10down-regulates activity img/direct_inhibition.png gtpase-activating protein RHOA 0.655
Publications: 1 Organism: Homo Sapiens