Summary

Name CASTOR2
Full Name Cytosolic arginine sensor for mTORC1 subunit 2
Synonyms Cellular arginine sensor for mTORC1 protein 2, GATS-like protein 2 | GATSL1, GATSL2
Primary ID A6NHX0
Links - -
Type protein
Relations 1
Function Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex. As part of homodimers or heterodimers with CASTOR1, directly binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Does not directly bind arginine, but binding of arginine to CASTOR1 disrupts the interaction of CASTOR2-containing heterodimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.

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Relations

Regulator Mechanism target score ℹ
+ CASTOR2form complex img/form-complex.png binding CASTOR1-CASTOR2 arginine binding complex 0.2
Publications: 1 Organism: Homo Sapiens