| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267760 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18554506 |
Very long-chain fatty acids are produced through a four-step cycle. However, the 3-hydroxyacyl-CoA dehydratase catalyzing the third step in mammals has remained unidentified. Mammals have four candidates, HACD1-4, based on sequence similarities to the recently identified yeast Phs1, although HACD3 and HACD4 share relatively weak similarity. We demonstrate that all four of these human proteins are indeed 3-hydroxyacyl-CoA dehydratases, |
|
3.0
HACD1
- 
- 
chemical activation