Relation Results

Summary

Name zaleplon
Synonyms 3'-(3-Cyanopyrazolo(1,5-a)pyrimidin-7-yl)-N-ethylacetanilide (ChemIDplus), zaleplon (KEGG DRUG)
IUPAC N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethylacetamide
Formula C17H15N5O
PRIMARY ID
(Read more)		 CHEBI:10102
Type chemical
Relations 1

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Type: Score: Layout: SPV 
0.8zaleplonGABA-A (a1-b1-g2) receptor

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Relations
Regulator
Mechanism
target
score ℹ
+ zaleplonup-regulates activity img/direct-activation.png chemical activation GABA-A (a1-b1-g2) receptor 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-263804 Homo sapiens
pmid sentence
The BZ-sensitive GABAA-Rs can be further subdivided, in that receptors containing the alpha1 subunit have a higher sensitivity to a subpopulation of BZ site ligands, the benzodiazepines quazepam and cinolazepam (Sieghart, 1989) or nonbenzodiazepines such as zolpidem (an imidazopyridine) and a few others, including CL218-872 (triazolopyridazine), zaleplon, and indiplon, and abecarnil (β-carboline), (Olsen and Gordey, 2000; Korpi et al., 2002; Sieghart and Ernst, 2005).
Publications: 1 Organism: Homo Sapiens
Tissue: Central Nervous System
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