Relation Results

Summary

Name valrubicin
Synonyms AD-32 (DrugCentral), N-Trifluoroacetyladriamycin 14-valerate (DrugCentral), N-Trifluoroacetyldoxorubicin 14-valerate (DrugCentral), valstar (DrugCentral)
IUPAC
Formula C34H36F3NO13
PRIMARY ID
(Read more)		 CHEBI:135876
Type chemical
Relations 2

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Type: Score: Layout: SPV 
0.80.8valrubicinTOP2ATOP2B

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Relations
Regulator
Mechanism
target
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+ valrubicindown-regulates activity img/direct_inhibition.png chemical inhibition TOP2A 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-259383 Homo sapiens
pmid sentence
Valrubicin (N-trifluoroacetyladriamycin-14-valerate) is a semi-synthetic derivative of the anthracycline doxorubicin. Valrubicin inhibits the incorporation of nucleosides into nucleic acids, causing extensive chromosomal damage and cell-cycle arrest in the G2 phase. Its principal metabolites inhibit topoisomerase II, thus arresting DNA synthesis.
Publications: 1 Organism: Homo Sapiens
+ valrubicindown-regulates activity img/direct_inhibition.png chemical inhibition TOP2B 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-259384 Homo sapiens Urinary Bladder Cell Line
pmid sentence
Valrubicin (N-trifluoroacetyladriamycin-14-valerate) is a semi-synthetic derivative of the anthracycline doxorubicin. Valrubicin inhibits the incorporation of nucleosides into nucleic acids, causing extensive chromosomal damage and cell-cycle arrest in the G2 phase. Its principal metabolites inhibit topoisomerase II, thus arresting DNA synthesis.
Publications: 1 Organism: Homo Sapiens
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