| + |
methylnaltrexone | down-regulates activity 
chemical inhibition
|
OPRM1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258148 |
|
|
Cricetulus longicaudatus |
|
| pmid |
sentence |
| 19282177 |
A series of novel high affinity opioid receptor ligands have been made whereby the phenolic-OH group of nalbuphine, naltrexone methiodide, 6-desoxonaltrexone, hydromorphone and naltrindole was replaced by a carboxamido group and the furan ring was opened to the corresponding 4-OH derivatives. These furan ring “open” derivatives display very high affinity for μ and κ receptors and much less affinity for δ. |
|
| Publications: |
1 |
Organism: |
Cricetulus Longicaudatus |
| + |
methylnaltrexone | down-regulates activity
chemical inhibition
|
OPRK1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258042 |
|
|
Cricetulus longicaudatus |
CHO Cell |
| pmid |
sentence |
| 19282177 |
A series of novel high affinity opioid receptor ligands have been made whereby the phenolic-OH group of nalbuphine, naltrexone methiodide, 6-desoxonaltrexone, hydromorphone and naltrindole was replaced by a carboxamido group and the furan ring was opened to the corresponding 4-OH derivatives. These furan ring “open” derivatives display very high affinity for μ and κ receptors and much less affinity for δ. |
|
| Publications: |
1 |
Organism: |
Cricetulus Longicaudatus |
| + |
methylnaltrexone | down-regulates activity
chemical inhibition
|
OPRD1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258147 |
|
|
Cricetulus longicaudatus |
CHO Cell |
| pmid |
sentence |
| 19282177 |
A series of novel high affinity opioid receptor ligands have been made whereby the phenolic-OH group of nalbuphine, naltrexone methiodide, 6-desoxonaltrexone, hydromorphone and naltrindole was replaced by a carboxamido group and the furan ring was opened to the corresponding 4-OH derivatives. These furan ring “open” derivatives display very high affinity for μ and κ receptors and much less affinity for δ. |
|
| Publications: |
1 |
Organism: |
Cricetulus Longicaudatus |
3.0
methylnaltrexone
