| + |
dUMP(2-) | up-regulates quantity
precursor of
|
dTMP(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268236 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21876188 |
In this pathway, 5,10-methyleneTHF, a one-carbon donor, is generated from serine by SHMT and used for the conversion of dUMP to dTMP in a reaction catalyzed by TYMS. The TYMS-catalyzed reaction generates dihydrofolate, which is converted to THF in an NADPH-dependent manner by DHFR. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TYMS | down-regulates quantity
chemical modification
|
dUMP(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268234 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21876188 |
In this pathway, 5,10-methyleneTHF, a one-carbon donor, is generated from serine by SHMT and used for the conversion of dUMP to dTMP in a reaction catalyzed by TYMS. The TYMS-catalyzed reaction generates dihydrofolate, which is converted to THF in an NADPH-dependent manner by DHFR. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |