Summary

Name TK2
Full Name Thymidine kinase 2, mitochondrial
Synonyms Mt-TK |
Primary ID O00142
Links - -
Type protein
Relations 8
Pathways Nucleotode Salvage
Function Phosphorylates thymidine, deoxycytidine, and deoxyuridine in the mitochondrial matrix. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on TK2 and DGUOK. Widely used as target of antiviral and chemotherapeutic agents.

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Relations

Regulator Mechanism target score
+ down-regulates quantity img/direct_inhibition.png chemical modification ATP(4-)
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png chemical modification ADP(3-)
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png chemical modification 2'-deoxycytidine
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png chemical modification 2'-deoxycytosine 5'-monophosphate(2-)
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png chemical modification thymidine
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png chemical modification dTMP(2-)
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png chemical modification 2'-deoxyuridine
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png chemical modification dUMP(2-)
Publications: 1 Organism: Homo Sapiens