+ |
bradykinin | up-regulates
chemical activation
|
BDKRB1 |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-152588 |
|
|
Homo sapiens |
Prostate Gland Cancer Cell, Small Cell Lung Cancer Cell |
pmid |
sentence |
17251915 |
Neuropeptides such as grp, endothelin, bradykinin, neuromedin b (nmb), cholecystokinin (cck) and angiotensin ii activate their cognate gpcrs to stimulate cell proliferation in various cell types, and have a crucial role in many aggressive human cancers, including small-cell lung cancer (sclc), pancreatic cancer, hnscc and prostate cancer. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
bradykinin | up-regulates activity
chemical activation
|
BDKRB1 |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-257464 |
|
|
Homo sapiens |
HEK-293A Cell |
pmid |
sentence |
31160049 |
Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signaling. | We defined positive coupling if any member of the subfamily scored LogRAi ≥ -1 and negative coupling if all of the members scored LogRAi < -1 (Figure 3A-B). ROC analysis gives AUC = 0.78 (Figure S4A) when considering high-confidence known coupling data and suggested a threshold of LogRAi ≥ -1.0 for defining true couplings. | The score associated to this interaction has a LogRAi ≥ -1.0. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
ACE | down-regulates quantity by destabilization
binding
|
bradykinin |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-253341 |
|
|
Homo sapiens |
|
pmid |
sentence |
16219810 |
The angiotensin-converting enzyme (ACE) is a membrane-bound peptidyl dipeptidase known to act on a variety of peptide substrates in the extracellular space. Its most notable functions are the formation of angiotensin II and the degradation of bradykinin. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | Focal segmental glomerulosclerosis |