Summary

Name ACE
Full Name Angiotensin-converting enzyme
Synonyms ACE, Dipeptidyl carboxypeptidase I, Kininase II | DCP, DCP1
Primary ID P12821
Links - -
Type protein
Relations 14
Pathways COVID-19 Causal Network, Fibrosis, Focal segmental glomerulosclerosis, SARS-CoV FIBROSIS
Inhibitors benazepril; fosinoprilat; trandolapril; lisinopril; captopril; ramipril; enalaprilat (anhydrous); enalapril
Function Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety.

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation ACE 0.307
Publications: 1 Organism: Sus Scrofa
Pathways:COVID-19 Causal Network
+ down-regulates activity img/direct_inhibition.png chemical inhibition ACE 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Focal segmental glomerulosclerosis
+ down-regulates activity img/direct_inhibition.png chemical inhibition ACE 0.8
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition ACE 0.8
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates activity img/direct-activation.png cleavage AGT 0.776
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Fibrosis, Focal segmental glomerulosclerosis, SARS-CoV FIBROSIS
+ up-regulates activity img/direct-activation.png binding ACE 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Fibrosis, SARS-CoV FIBROSIS
+ down-regulates activity img/direct_inhibition.png chemical inhibition ACE 0.8
Publications: 2 Organism: In Vitro
+ down-regulates quantity by destabilization img/direct_inhibition.png binding bradykinin 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Focal segmental glomerulosclerosis
+ down-regulates activity img/direct_inhibition.png chemical inhibition ACE 0.8
Publications: 1 Organism: In Vitro
+ up-regulates quantity img/direct-activation.png cleavage Angiotensin-2 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Fibrosis, SARS-CoV FIBROSIS
+ down-regulates activity img/direct_inhibition.png chemical inhibition ACE 0.8
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition ACE 0.8
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png chemical inhibition ACE 0.8
Publications: 1 Organism: Rattus Norvegicus