Relation Results

Summary

Name 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine
Synonyms (R)-7-(acetyloxy)-4-hydroxy-N,N,N-trimethyl-3,5,9-trioxa-4-phosphapentacosan-1-aminium hydroxide inner salt 4-oxide (ChEBI), 1-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (LIPID MAPS), 1-O-hexadecyl PAF (ChEBI), 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (UniProt), 1-O-hexadecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine (ChemIDplus), 1-O-hexadecyl-2-O-acetyl-sn-glycero-3-phosophocholine (ChemIDplus), 1-O-hexadecyl-2-O-acetyl-sn-glyceryl-3-phosphorylcholine (ChemIDplus), 1-O-hexadecyl-platelet-activating factor (ChemIDplus), C16 PAF (ChEBI), C16-PAF (ChEBI), C16:0 PAF (ChEBI), PAF (ChEBI), Platelet activating factor (ChemIDplus), platelet-activating factor (ChEBI), platelet-activating factor C16 (ChemIDplus)
IUPAC (2R)-2-acetoxy-3-(hexadecyloxy)propyl 2-(trimethylammonio)ethyl phosphate
Formula C26H54NO7P
Primary ID CHEBI:44811
Type small molecule
Relations 1

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Type: Score: Layout: SPV 
0.82-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholinePTAFR

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Relations
Regulator
Mechanism
target
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+ 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholineup-regulates activity img/direct-activation.png chemical activation PTAFR 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-257567 Homo sapiens HEK-293A Cell
pmid sentence
Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signaling. | We defined positive coupling if any member of the subfamily scored LogRAi ≥ -1 and negative coupling if all of the members scored LogRAi < -1 (Figure 3A-B). ROC analysis gives AUC = 0.78 (Figure S4A) when considering high-confidence known coupling data and suggested a threshold of LogRAi ≥ -1.0 for defining true couplings. | The score associated to this interaction has a LogRAi ≥ -1.0.
Publications: 1 Organism: Homo Sapiens
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