| + |
Diprenorphine | down-regulates activity 
chemical inhibition
|
OPRK1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258662 |
|
|
Cricetulus griseus |
CHO Cell |
| pmid |
sentence |
| 9262330 |
We recently cloned a human kappa opioid receptor and stably expressed it in Chinese hamster ovary (CHO) cells. In this study, the effects of activation of the human kappa receptor by agonists on [35S]GTPgammaS binding to CHO cell membranes were examined.. The rank order of potencies of opioid ligands tested in stimulating [35S]GTPgammaS binding was dynorphin A 1-17 > (+/-)-ethylketocyclazocine > beta-funaltrexamine, (-)-U50,488H, tifluadom > nalorphine > pentazocine, nalbuphine > buprenorphine. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258791 |
|
|
Cricetulus griseus |
CHO Cell |
| pmid |
sentence |
| 9686407 |
Accordingly, for the OTDP, the binding affinity and activity of a large number of opiate compounds have been tested at μ-, δ-, and κ-opiate receptors. Binding studies were originally conducted in guinea pig brain membranes, and subsequent studies have been carried out in CHO cells transfected with human receptors. Table 7 shows a biochemical method for determining activity and potency of opioid compounds, stimulation of [35S]GTPγS binding in membranes from cells transfected with human μ, δ, or κ receptors. |
|
| Publications: |
2 |
Organism: |
Cricetulus Griseus |
| + |
Diprenorphine | down-regulates activity
chemical inhibition
|
OPRM1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258789 |
|
|
Cricetulus griseus |
CHO Cell |
| pmid |
sentence |
| 9686407 |
Accordingly, for the OTDP, the binding affinity and activity of a large number of opiate compounds have been tested at μ-, δ-, and κ-opiate receptors. Binding studies were originally conducted in guinea pig brain membranes, and subsequent studies have been carried out in CHO cells transfected with human receptors. Table 7 shows a biochemical method for determining activity and potency of opioid compounds, stimulation of [35S]GTPγS binding in membranes from cells transfected with human μ, δ, or κ receptors. |
|
| Publications: |
1 |
Organism: |
Cricetulus Griseus |
| + |
Diprenorphine | up-regulates activity 
chemical activation
|
OPRD1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258790 |
|
|
Cricetulus griseus |
CHO Cell |
| pmid |
sentence |
| 9686407 |
Accordingly, for the OTDP, the binding affinity and activity of a large number of opiate compounds have been tested at μ-, δ-, and κ-opiate receptors. Binding studies were originally conducted in guinea pig brain membranes, and subsequent studies have been carried out in CHO cells transfected with human receptors. Table 7 shows a biochemical method for determining activity and potency of opioid compounds, stimulation of [35S]GTPγS binding in membranes from cells transfected with human μ, δ, or κ receptors. |
|
| Publications: |
1 |
Organism: |
Cricetulus Griseus |
3.0
Diprenorphine
