| + |
MTHFD2L | up-regulates quantity 
chemical modification
|
(6R)-5,10-methenyltetrahydrofolate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268252 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 21163947 |
Conversion of these 1-carbon units to formate requires several folate-interconverting enzymes in mitochondria. The enzyme(s) responsible for conversion of 5,10-methylene-tetrahydrofolate (CH(2)-THF) to 10-formyl-THF in adult mammalian mitochondria are currently unknown. A new mitochondrial CH(2)-THF dehydrogenase isozyme, encoded by the MTHFD2L gene, has now been identified. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
MTHFD1 | up-regulates quantity
chemical modification
|
(6R)-5,10-methenyltetrahydrofolate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268249 |
|
|
in vitro |
|
| pmid |
sentence |
| 18767138 |
Methylenetetrahydrofolate dehydrogenase)methenyltetrahydrofolate cyclohydrolase)formyltetrahydrofolate synthetase (MTHFD1) is a trifunctional enzyme that interconverts tetrahydrofolate (THF) derivatives for nucleotide synthesis.|The Arg653Gln substitution is located in the synthetase domain, which catalyzes the magnesium adenosine triphosphate (MgATP)-dependent production of formylTHF from THF and formate |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | One-carbon Metabolism |
| + |
MTHFD2 | up-regulates quantity
chemical modification
|
(6R)-5,10-methenyltetrahydrofolate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268255 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16100107 |
Magnesium and phosphate ions enable NAD binding to methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase|One of the enzymes in this pathway, the NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase (NMDMC),5 catalyzes the interconversion of 5,10-methylenetetrahydrofolate (methylene-THF) and 10-formyltetrahydrofolate (formyl-THF) in mammalian mitochondria. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
(6R)-5,10-methylenetetrahydrofolate(2-) | up-regulates quantity
precursor of
|
(6R)-5,10-methenyltetrahydrofolate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268246 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18767138 |
Methylenetetrahydrofolate dehydrogenase)methenyltetrahydrofolate cyclohydrolase)formyltetrahydrofolate synthetase (MTHFD1) is a trifunctional enzyme that interconverts tetrahydrofolate (THF) derivatives for nucleotide synthesis.|The Arg653Gln substitution is located in the synthetase domain, which catalyzes the magnesium adenosine triphosphate (MgATP)-dependent production of formylTHF from THF and formate |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | One-carbon Metabolism |
| + |
(6R)-5,10-methenyltetrahydrofolate | up-regulates quantity
precursor of
|
10-formyltetrahydrofolate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268247 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18767138 |
Methylenetetrahydrofolate dehydrogenase)methenyltetrahydrofolate cyclohydrolase)formyltetrahydrofolate synthetase (MTHFD1) is a trifunctional enzyme that interconverts tetrahydrofolate (THF) derivatives for nucleotide synthesis.|The Arg653Gln substitution is located in the synthetase domain, which catalyzes the magnesium adenosine triphosphate (MgATP)-dependent production of formylTHF from THF and formate |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | One-carbon Metabolism |
3.0
(6R)-5,10-methenyltetrahydrofolate