One-carbon Metabolism

Pathway ID: SIGNOR-FM

Description: One-carbon (1C) metabolism, mediated by the folate cofactor, supports multiple physiological processes. These include biosynthesis (purines and thymidine), amino acid homeostasis (glycine, serine, and methionine) and epigenetic maintenance.

Curated by: Livia Perfetto

26 Seed Entities

Organism:
Name Primary ID
(6R)-5,10-methylenetetrahydrofolate(2-) CHEBI:15636
(6R)-5,10-methenyltetrahydrofolate CHEBI:57455
Purine biosynthesis SIGNOR-PH186
Food intake SIGNOR-PH152
MTR Q99707
TYMS P04818
Glycine cleavage system SIGNOR-C437
homocysteine CHEBI:17230
10-formyltetrahydrofolate(2-) CHEBI:57454
formate CHEBI:15740
dihydrofolate(2-) CHEBI:57451
L-serine CHEBI:17115
(6S)-5,6,7,8-tetrahydrofolate(2-) CHEBI:57453
SFXN1 Q9H9B4
methionine CHEBI:16811
(6S)-5-methyltetrahydrofolate(2-) CHEBI:18608
Chromatine_condensation SIGNOR-PH21
glycine CHEBI:15428
carbon dioxide CHEBI:16526
SHMT1 P34896
DHFR P00374
pyruvate CHEBI:15361
MTHFR P42898
folic acid CHEBI:27470
MTHFD1 P11586
SHMT2 P34897