+ |
ADSL | up-regulates quantity
chemical modification
|
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-) |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-266608 |
|
|
Homo sapiens |
|
pmid |
sentence |
22812634 |
ADSL carries out two non-sequential steps of de novo AMP synthesis, the conversion of succinylaminoimidazolecarboxamide ribonucleotide (SAICAR) and succinyladenosine monophosphate (SAMP) into aminoimidazolecarboxamide ribotide (AICAR) and adenosine monophosphate (AMP), respectively, with the concomitant release of fumarate in each case |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | Nucleotide Biosynthesis |
+ |
SAICAR(4-) | up-regulates quantity
precursor of
|
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-) |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-266609 |
|
|
Homo sapiens |
|
pmid |
sentence |
22812634 |
ADSL carries out two non-sequential steps of de novo AMP synthesis, the conversion of succinylaminoimidazolecarboxamide ribonucleotide (SAICAR) and succinyladenosine monophosphate (SAMP) into aminoimidazolecarboxamide ribotide (AICAR) and adenosine monophosphate (AMP), respectively, with the concomitant release of fumarate in each case |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | Nucleotide Biosynthesis |
+ |
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-) | up-regulates quantity
precursor of
|
(6S)-5,6,7,8-tetrahydrofolate(2-) |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-267323 |
|
|
Homo sapiens |
|
pmid |
sentence |
33179964 |
The last two steps in the pathway are catalyzed by the bifunctional AICAR transformylase/IMP cyclohydrolase (ATIC). The transformylase domain of the enzyme first catalyzes the conversion of AICAR to formylaminoimida zole-4-carboxamide ribonucleotide (FAICAR) using the N10-formyltetrahydrofolate. Then, the cyclohydrolase domain closes the purine ring to form IMP. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | Nucleotide Biosynthesis |