| + |
UPP1 | down-regulates quantity 
chemical modification
|
2-deoxy-D-ribofuranose 1-phosphate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280534 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21855639 |
Uridine phosphorylase (UPP) catalyzes the reversible conversion of uridine to uracil and ribose-1-phosphate and plays an important pharmacological role in activating fluoropyrimidine nucleoside chemotherapeutic agents such as 5-fluorouracil and capecitabine. Most vertebrate animals, including humans, possess two homologs of this enzyme (UPP1 & UPP2), of which UPP1 has been more thoroughly studied and is better characterized |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
UPP2 | down-regulates quantity
chemical modification
|
2-deoxy-D-ribofuranose 1-phosphate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280538 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21855639 |
Uridine phosphorylase (UPP) catalyzes the reversible conversion of uridine to uracil and ribose-1-phosphate and plays an important pharmacological role in activating fluoropyrimidine nucleoside chemotherapeutic agents such as 5-fluorouracil and capecitabine. Most vertebrate animals, including humans, possess two homologs of this enzyme (UPP1 & UPP2), of which UPP1 has been more thoroughly studied and is better characterized |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PNP | down-regulates quantity
chemical modification
|
2-deoxy-D-ribofuranose 1-phosphate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280545 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 35063692 |
Purine nucleoside phosphorylase (PNP) is a key enzyme in the purine salvage pathway. Inosine and guanosine and the respective deoxynucleosides are substrates of this enzyme. Adenosine and deoxyadenosine are mainly deaminated by adenosine deaminase respectively to inosine and deoxyinosine which are in turn catabolized by PNP |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280553 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 35063692 |
Purine nucleoside phosphorylase (PNP) is a key enzyme in the purine salvage pathway. Inosine and guanosine and the respective deoxynucleosides are substrates of this enzyme. Adenosine and deoxyadenosine are mainly deaminated by adenosine deaminase respectively to inosine and deoxyinosine which are in turn catabolized by PNP |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
4.0
2-deoxy-D-ribofuranose 1-phosphate(2-)