+ |
ketanserin | down-regulates activity
chemical inhibition
|
HTR2B |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-258685 |
|
|
Mesocricetus auratus |
Fibroblast |
pmid |
sentence |
9459568 |
The data in Table 2 show the affinity of a number of compounds for the [3H]rauwolscine labeled human 5-HT2B receptor. All of the competition curves for these compounds yielded slope values that were near unity, i.e, they did not significantly fit a two-site binding model better than a one-site binding model. sured against [3H]rauwolscine (Fig. 4), as would be expected since antagonists typically do not discriminate between the agonist high- and low-affinity states. Note that the correlation line is about 0.25 log units from the line of identity, while still having a slope near unity. In fact many compounds, including haloperidol, m-CPP, rauwolscine, ritanserin, spiroxatrine, yohimbine and 1-NP displayed significantly higher affinity for the [3H]rauwolscine than for the [3H]5-HT labeled human 5-HT2B receptor. measured against [3H]5-HT versus the pKi when mea- |
|
Publications: |
1 |
Organism: |
Mesocricetus Auratus |
+ |
ketanserin | down-regulates activity
chemical inhibition
|
SLC18A1 |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-258493 |
|
|
Homo sapiens |
CV-1 Cell |
pmid |
sentence |
8643547 |
Reserpine and ketanserin are slightly more potent inhibitors of VMAT2-mediated transport than of VMAT1-mediated transport, whereas tetrabenazine binds to and inhibits only VMAT2. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
ketanserin | down-regulates activity
chemical inhibition
|
SLC18A2 |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-258494 |
|
|
Homo sapiens |
CV-1 Cell |
pmid |
sentence |
8643547 |
Reserpine and ketanserin are slightly more potent inhibitors of VMAT2-mediated transport than of VMAT1-mediated transport, whereas tetrabenazine binds to and inhibits only VMAT2. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |